Allegra has no brain interference and no sedative effect1
For patients with tough allergy symptoms, that's a no-brainer
Every patient is different and can have a variety of symptoms.* Allegra provides powerful allergy relief for patients with itchy, watery eyes, itchy throat, runny nose, and sneezing.† It starts working in 1 hour and doesn't cause drowsiness. That's why it’s the #1 allergist-recommended non-drowsy OTC antihistamine brand.‡
No Brain Interference from Drowsiness
Allegra has no brain interference and no sedative effect1
- Fexofenadine, the antihistamine molecule in Allegra is proven in several controlled studies to have 0% brain interference
- Any brand that has less than 20% brain occupancy can claim to be non-drowsy
- Brands like Zyrtec can cause drowsiness which can impact cognitive performance
- Although Claritin can claim non-drowsy, the reality is that it can enter the brain and create a 13%-26% occupancy
Brain histamine H1-receptor occupancies of various antihistamines and classification for sedating actions. The occupancy data are represented as the mean +/- SD of measurements in positron emission tomography after oral single-dose administration of the drugs
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Efficacy
Allegra acts fast
It starts acting in 1 hour (applies for the first intake)1
The median reported onset of allergic rhinitis symptom relief for fexofenadine 180mg and 60mg is 1 hour for both dosages1
One hundred forty-six subjects who adequately responded to priming entered a single-dose placebo phase. Placebo-responders were disqualified from the study, leaving other subjects with adequate symptoms to be randomized and given a single dose of either fexofenadine HCl 120 mg, 60 mg or placebo, after 60 minutes of allergen exposure.
Allegra® Products
Get relief from the #1 allergist-recommended non-drowsy OTC antihistamine brand‡ for tough allergy symptoms* with Allegra® Allergy, Allegra-D®, and Children's Allegra® products.
Allergy Relief
Allergy & Congestion Relief
Hives Relief
Relief for Kids
FAQs
No. Allegra-D® does not include phenylephrine. It's formulated with pseudoephedrine (PSE), a clinically proven ingredient for nasal congestion relief.
No, Allegra® Allergy 24-hour tablets do not contain phenylephrine (PE). The active ingredient in these products is fexofenadine, a non-drowsy antihistamine. Fexofenadine effectively relieves allergy symptoms such as sneezing, runny nose, itchy/watery eyes, and an itchy nose or throat. These symptoms can be caused by hay fever or other upper respiratory allergies.
No, Children's Allegra® Allergy relief does not have phenylephrine in its formulation. Children's Allegra® is formulated with Fexofenadine HCl, a non-drowsy antihistamine that works to relieve allergy symptoms of sneezing, runny nose, itchy/watery eyes, and itchy nose or throat due to hay fever or other upper respiratory allergies.
No, Allegra® Hives does not have phenylephrine in its formulation. It is made with Fexofenadine HCl, a non-drowsy antihistamine that reduces hives and relieves the itching caused by hives.
- Ansotegui IJ, Bousquet J, Canonica GW, et al. Why fexofenadine is considered as a truly non-sedating antihistamine with no brain penetration: a systematic review. Curr Med Res Opin. 2024 Aug;40(8):1297-1309.
*Symptoms include itchy, watery eyes; itchy nose or throat; rhinorrhea; and sneezing.
†See Drug Facts label. Use as directed.
‡Among single-ingredient branded OTC oral antihistamines.