반려동물 알레르기: 증상과 치료

1. Asthma and Allergy Foundation of America, Editors. Pet Allergy Are You Allergic to Dogs or Cats?, Asthma and Allergy Foundation of America (aafa.org), 2015.

2. American College of Allergy, Asthma & Immunology, Editors. Pet Allergy, American College of Allergy, Asthma & Immunology (acaai.org), 2018.

3. Olasińska-Wiśniewska A, et al. Cardiovascular safety of antihistamines. Postępy Dermatologii i Alergologii. 2014.31(3);182-186

4. Bousquet J et al. Allergic Rhinitis. Nat Rev Dis Primers. 2020.6(95);1-17

5. Mark E et al. Efficacy and tolerability of 2nd and 3rd gen antihistamines. ANNALS OF ALLERGY, ASTHMA & IMMUNOL. 2010.104;518–522

6. Fein MN et al. CSACI position statement_Newer generation H1-antihistamines (3rd generation) are safer than first-generation H1-antihistamines. Allergy Asthma Clin Immunol. 2019.15(61);1-6

7. Anne K et al. Second-and third-generation antihistamines. DERMATOLOGIC THERAPY. 2000.13;327–336

8. Thomas B et al. Next generation antihistamines therapeutic rationale accomplishments and advances. Expert Opinion on Investigational Drugs. 2002.11(6);807-817

9. Day J H et al. Onset of action, efficacy, and safety of a single dose of fexofenadine hydrochloride. Ann Allergy Asthma Immunol. 1997.79;533-540.

10. Smith SM et al. Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opinion on Drug Metabolism & Toxicology. 2009;5(7);813-22

11. Peter H. Double-blind, placebo-controlled study. Comparing the efficacy and safety of fexofenadine and cetirizine in seasonal AR. J ALLERGY CLIN IMMUNOL. 1999;104(5);927-33

12. Van Cauwenberge et al. Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg. Clin Exp Allergy. 2000. 30(6);891-899

[Study Design⁹] This study was of a randomized, placebo-controlled, double-blind, parallel design. The purpose of this study was to characterize the time to onset of clinically important relief of symptoms of allergic rhinitis in subjects taking single doses of either 60 mg or 120 mg fexofenadine HCl, or placebo, after exposure to ragweed pollen in a controlled environment. Other objectives were to assess the efficacy and safety of single doses of fexofenadine HCl.

[Study Design¹¹] A multicenter, double-blind, parallel-group, placebo-controlled trial compared the efficacy and safety of fexofenadine HCl (120 and 180 mg administered once daily) and cetirizine (10 mg once daily) in the treatment of seasonal allergic rhinitis. The primary efficacy variable was the change in mean 24-hour reflective TSS during the treatment period in relation to the single blind placebo lead-in phase.

[Study Design¹²] This was a multinational, multicentre, double-blind, parallel group, randomized, placebo-controlled study. Following a placebo run-in phase of 3±7 days (the baseline period), patients with SAR were to receive one capsule of either fexofenadine HCl 120mg(n=232), loratadine 10mg(n=228), or placebo(n=225), once each morning for 14 days. The primary efficacy parameter was the change in the mean 24-h reflective TSS during the double-blind treatment period from that during the baseline period.