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Understanding Allegra-D's Active Ingredients: The Science Behind Allergy and Congestion Relief
Discover the dual-action formula of Allegra-D that offers comprehensive relief from seasonal allergies and congestion.
The signs and symptoms of allergies, common colds, and other illnesses can have many similarities—making it difficult to figure out how to best relieve your symptoms. But there are a few ways to identify which is which and continue living your greatness, by understanding the most common allergy symptoms to look out for.1
What are the active ingredients in Allegra-D?
When it comes to finding relief from seasonal allergies with congestion, Allegra-D stands out as a go-to medication for many. At the core of its effectiveness are two primary active ingredients: Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride. Together, these compounds form a powerful duo that targets a range of symptoms, offering a comprehensive solution for those struggling with allergic reactions and nasal congestion.
Fexofenadine Hydrochloride: The Antihistamine Powerhouse
Fexofenadine Hydrochloride, commonly known as Fexofenadine, is a second-generation antihistamine. Unlike its first-generation counterparts, which often cause drowsiness, Fexofenadine is designed to minimize such side effects. It is effective in alleviating allergy symptoms like sneezing, runny nose, and itchy or watery eyes.
Pseudoephedrine Hydrochloride: The Decongestant Dynamo
The "D" in Allegra-D stands for Decongestant and Pseudoephedrine is the specific decongestant in Allegra-D. Pseudoephedrine is the most potent oral decongestant ingredient that is available over-thecounter (OTC) at the pharmacy. This powerful compound acts as a beacon of relief for individuals plagued by the discomfort of nasal and sinus congestion. Tracing its roots to the Ephedra family, pseudoephedrine boasts a storied medicinal history, spanning over 5,000 years in China and 2,000 years in the Middle East1 . Its efficacy lies in its ability to constrict the blood vessels within the nasal passages, thereby diminishing swelling and facilitating easier breathing. In simple terms, just one dose of pseudoephedrine could make a big difference in relieving nasal congestion, making it more effective than another common oral decongestant, phenylephrine (PE) 7.
What is the Science Behind Allegra-D?
We've all been there—sniffling, sneezing, and feeling congested when seasonal allergies hit. It's not just uncomfortable; it's downright frustrating. So, how does Allegra-D offer that much-needed relief when other medications fall short? Let's delve into the science behind its active ingredients to find out.
The Role of Histamines in Allergies
When an allergen invades your system, your body's natural defense mechanism kicks in, releasing a substance called histamine. While histamine serves a protective role, it's also the culprit behind those pesky allergy symptoms like itchy eyes and a runny nose.
Fexofenadine: Blocking Histamines
Fexofenadine comes into play here as a non-drowsy antihistamine. It blocks the effects of histamine, effectively reducing allergy
symptoms2.
Pseudoephedrine: Tackling Nasal Congestion
If you've ever felt like your face was being squeezed by an invisible hand, you're not alone. That sensation is sinus pressure, and it's as uncomfortable as it sounds. Pseudoephedrine, the "D" in Allegra-D, targets this discomfort by narrowing the blood vessels in your nasal passages. The result? Easier breathing and less facial discomfort3.
The Combined Effectiveness of Fexofenadine and Pseudoephedrine
When used in combination, these two active ingredients offer a comprehensive solution. Fexofenadine addresses the sneezing, runny nose, and itchy eyes, while Pseudoephedrine focuses on alleviating nasal and sinus congestion. In synergy, Allegra-D starts working in as little as 45 minutes, helping you return to your normal self by improving your symptoms and allowing you to carry on with your daily activities and work4.
"Having Allergies can be downright miserable. At times they can make just getting through the day seem like the biggest hurdle. I have tried many allergy pills that make tons of promises that fail. This product actually gets me through 24hrs and keeps me feeling normal and living my life!"
- Danielleg170
Allegra-D® Allergy & Congestion 24 Hour Tablets
Originally posted on influenster.com
What is the Dosage for Allegra-D?
The right dosage ensures that you get the maximum benefits from Allegra-D. Always follow the recommended dosage and consult with a healthcare professional if you are unsure.
For Adults and Children 12 Years and Older:
- Allegra-D 12-hour relief: Take 1 tablet with a glass of water every 12 hours on an empty stomach; do not take more than 2 tablets in 24 hours
- Allegra-D 24-hour relief: Take 1 tablet with a glass of water every 24 hours on an empty stomach;do not take more than 1 tablet in 24 hours
- For Children Under 12 Years: do not use.
- For Adults 65 years of age and older: ask a doctor.
- For Consumers with kidney disease: ask a doctor.
**If pregnant or breastfeeding, ask a health professional before use.
Important Notes
- Always swallow the tablet whole. Do not crush, chew, dissolve or break it.
- In case of an overdose, get medical help or contact a Poison Control Center right away.
What are the Safety and Precautions Warnings?
DO NOT USE:
- If you have ever had an allergic reaction to this product or any of its ingredients
- If you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- If you have difficulty swallowing
Ask a doctor before use if you have:
- Heart disease
- Thyroid disease
- Glaucoma
- High blood pressure
- Diabetes
- Trouble urinating due to an enlarged prostate gland.
- Kidney disease. Your doctor should determine if you need a different dose.
**If pregnant or breastfeeding, ask a health professional before use.
Where can I get the full product labeling?
Remember, while Allegra-D provides effective relief from allergy symptoms, it is crucial to take it responsibly. If you experience any side effects or if your symptoms do not improve, consult with a healthcare professional.
Where can I buy Allegra-D?
Allegra-D® 24-hour and 12-hour tablets are available at pharmacies in most US states without a prescription, except in Mississippi and Oregon, where a prescription is required. Remember, all products that contain pseudoephedrine are being sold behind-the-counter and through interaction with a pharmacist (in line with the US laws and regulations that limit the sale of PSE by pharmacies). To purchase pseudoephedrine a person must:
- Present a photo identification card issued by the State or the Federal Government.
- The pharmacist will enter your information into a logbook.
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Related Articles
- Głowacka, K. (2021). Pseudoephedrine—Benefits and risks. International Journal of Molecular Sciences, 22, 5146.
- NHS UK. (2023). Antihistamines. Retrieved September 21, 2023, from https://www.nhs.uk/conditions/antihistamines/
- Mansfield E. Once-daily immediate-release fexofenadine and sustained-release pseudoephedrine combination: a new treatment option for allergic rhinitis, Expert Opinion on Pharmacotherapy, 2006, 7:7, 941-951.
- Simpson, J. (2000). Fexofenadine: A review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria. Drugs, 59(2), 301-321.
- Transportation Security Administration. (2023). Can you pack your meds, pill case, and more questions answered. Retrieved September 21, 2023, from https://www.tsa.gov/travel/travel-tips/can-you-pack-your-meds-pill-case-and-more-questions-answered
- World Anti-Doping Agency. (2021). TUE physician guidelines – Sinusitis/Rhinosinusitis (Version 2.0). Retrieved September 21, 2023, from https://www.wadaama.org/sites/default/files/resources/files/tue_physician_guidelines_sinusitis_rhin osinusitis.pdf
- Horak et al. A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna Challenge Chamber. Ann Allergy Asthma Immunol. 2009 Feb;102(2):116-20.
*Allegra is indicated to relieve sneezing, runny nose, itchy, watery eyes, and itchy nose or throat. Allegra-D is indicated to relieve sneezing, runny nose, itchy, watery eyes, itchy nose or throat, nasal congestion, sinus pressure, and reduce swelling of the nasal passages.
†Among single-ingredient branded OTC oral antihistamines and OTC multi-ingredient allergy & decongestant brands.
This article is not a substitute for medical advice. Allegra should be used as directed according to the product label. If you suspect that you have allergies, consult with your doctor or an allergist. Only they can make a proper diagnosis.